Delays in diagnosis are common, leading to disease progression and worsening clinical outcomes2,5
Prolonged exposure to excess, accumulated arginine results in neurological, developmental, and functional manifestations that eventually lead to functional disability and the impairment of daily living activities.2,6,7

Infancy

Toddlerhood

Childhood

Adolescence

Adulthood
The potential impact of ARG1‑D
Learn about delays in diagnosis and long-term disease progression

If you suspect your patient may have ARG1‑D
Early diagnosis of ARG1‑D could potentially reduce the burden of the disease.1,8 Order a no-charge sponsored genetic test*
*Eligibility requirements apply.
References:
1. Diez-Fernandez C et al. Hum Mutat. 2018;39:1029-1050. 2. Carvalho DR et al. Pediatr Neurol. 2012;46:369-374. 3. Häberle J et al. J Inherit Metab Dis. 2019;1-39. 4. De Deyn PP et al. In: De Deyn PP et al, eds. Guanidino Compounds in Biology and Medicine. London, UK: John Libbey & Company Ltd; 1997:53-69. 5. Huemer M et al. J Inherit Metab Dis. 2016;39:331-340. 6. Bakhiet M et al. Medicine (Baltimore). 2018;97:e10780. 7. Crombez EA, Cederbaum SD. Mol Genet Metab. 2005;84:243-251. 8. Edwards RL et al. J Inherit Metab Dis. 2009;32:S197-S200.