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Continue learning about Arginase 1 Deficiency (ARG1‑D) with these helpful resources and tools



Could it Be ARG1-D?

It is crucial to diagnose and manage ARG1‑D without delay. Here are some of the ways to identify the signs and symptoms.



The Impact of ARG1-D

Prolonged exposure to uncontrolled arginine levels has been associated with disease progression.1,2
Persistently elevated levels of arginine distinguish ARG1‑D from other neurometabolic and neurologic disorders3



The Impact of Misdiagnosis

ARG1‑D may be misdiagnosed as Hereditary Spastic Paraplegia (HSP) or Cerebral Palsy (CP) at initial presentation, as these diseases have overlapping manifestations4

HSP Patient Case Study*

A case study of a ARG1-D patient that was originally misdiagnosed with HSP 

References:
1. Bakhiet M et al. Medicine (Baltimore). 2018;97:e10780.
2. Crombez EA, Cederbaum SD. Mol Genet Metab. 2005;84:243-251.
3. De Deyn PP et al. In: De Deyn PP et al, eds. Guanidino Compounds in Biology and Medicine. London, UK: John Libbey & Company Ltd; 1997:53-69.
4. Carvalho DR et al. Pediatr Neurol. 2012;46:369-374.
*Hypothetical patient profile based on clinical data from ARG1-D patients.